First, neutrophils, which are the most common innate immune cells, have been documented to facilitate tumor invasion and metastasis through the secretion of vascular endothelial growth factor A (VEGFA), matrix metalloproteinases (MMPs), and other chemokines such as interleukin-6 (IL-6) and transforming growth factor-beta (TGF-β) (36). This evidence concerns the gene VEGFA and neoplasm.