TRPC1 and fragile X syndrome: However, inhibiting TRPC1 reduced memory extinction seen in FXS mice (Figure 2G), where FXS C1-cKO spent a significantly higher time, in the target quadrant on day 22 (FXS C1: mean = 11.4 ± 1.4, FXS C1-cKO: mean = 20.5 ± 2.1, p = 0.004) and 23 (FXS C1: mean = 10.05 ± 2.3, FXS C1-cKO: mean = 18.03 ± 1.7, p = 0.017) of the test than FXS C1, suggesting an important role of TRPC1 in memory extinction process.