qPCR on hippocampal samples revealed a decrease in Trpc1 gene expression by 70.3% in FXS C1-cKO compared to their control littermates FXS C1 (FXS C1: mean = 100% ± 3.8, FXS C1-cKO: mean = 29.7% ± 7.7, p = 0.02) (Figure 1A). Here, TRPC1 is linked to fragile X syndrome.