GRIA1 and fragile X syndrome: Indeed, the internalized index (internalized/total receptors) presented in Figure 4B shows a significant increase in the internalization of GluA1 only in FXS C1 group 60 min following DHPG treatment (FXS C1 non treated: mean = 0.46 ± 0.01, FXS C1 +DHPG: mean = 0.55 ± 0.03, p = 0.009) and not in FXS C1-cKO group (FXS C1-cKO non treated: mean = 0.45 ± 0.01, FXS C1-cKO +DHPG: mean = 0.48 ± 0.01, p = 0.25; p (FXS C1+DHPG vs. FXS C1-cKO+ DHPG) = 0.019).