TRPC1 and fragile X syndrome: Interestingly, inhibiting TRPC1 expression completely abolished mGluR-LTD response, in FXS C1-cKO, where synaptic strength returned to near baseline levels and was stabilized at around 100% of the pre-stimulation level, 60 min post-DHPG (Figures 3A and 3B) (fEPSP slope 60 min post DHPG: FXS C1: mean = 70.8% ± 12.63, FXS C1-cKO: mean = 99.9% ± 4.58, p = 0.026).