Western blot analysis demonstrated a decrease in TRPC1 protein expression in the hippocampus of FXS C1-cKO compared to FXS C1 (Figures 1B and 1C) (FXS C1: mean = 0.28 ± 0.01, FXS C1-cKO: mean = 0.15 ± 0.02, p = 0.01). This evidence concerns the gene TRPC1 and fragile X syndrome.