It may appear surprising that the complete inhibition of protein synthesis does not affect mGluR-LTD in FXS mice (see Figure S5), whereas deleting TRPC1 abolishes mGluR-LTD (FXS C1-cKO mice, see Figure 3A), knowing that increasing the expression of ARC protein (and probably other proteins), mimicking the action of peEF2, is sufficient to rescue mGluR-LTD in these FXS C1-cKO mice. The gene discussed is ARC; the disease is fragile X syndrome.