Proteins encoded by those genes are involved in immune responses and neuronal functions: CCL2, a member of the monocyte chemokine protein family, induce monocyte infiltration and mediate inflammation to contribute to brain injury after stroke (68); Tuba1b is associated with the immune cell infiltration (69); Tubb5 influence the terminal differentiation and dendritic spine densities of cerebral cortical neurons (70). This evidence concerns the gene CCL2 and Stroke.