The heatmap of the IMvigor210 cohort suggested that a high-risk score was closely associated with EMT, hypoxia, myeloid-derived suppressor cells (MDSC), and gene signatures featuring stromal components, including cancer associated fibroblast (CAF) and TGF-β family members (Supplementary Figure S5A), which was similar with the above results. Here, TGFB1 is linked to cancer.