ATCL06, more prevalent in SP-RA than in SN-RA (Supplementary Figure 6B), mirrored the phenotype of activated Th1-type Tph-like cells, characterized by CXCR3+, CCR5+, and CCR6−, similar to TCL21 (Supplementary Figure 5C). The gene discussed is TPH1; the disease is rheumatoid arthritis.