CD4 and neoplasm: It noted that these genes were positively associated with tumor-promoted effectors, and those responsible for poor immunity, including M2 macrophages, resting CD4 T cells, resting mast cells, and naïve B cells, whereas they were negatively associated with the expression of helper T cells, activated CD4 T cells, plasma cells, M0/M1 macrophages and activated DCs, which were contributed to activated tumor immunity.