Our previous study has confirmed that TxA2 plays an important role in RA pathology through regulating synovial cell proliferation; TBXA2R, as the receptor of TxA2, could bind to TxA2 to activate the NF-κB signaling pathway and positively regulate osteoclastogenesis, whose blockage might prevent the inflammatory process from causing bone loss and bone deterioration (46). This evidence concerns the gene NFKB1 and rheumatoid arthritis.