These genes (SREBF1, SCD, PPARG, PPARA, INSR, FASN, CD36, ACADVL, ACADM, ACACA) were integrated into a predictive nomogram model based on a constructed RF model for forecasting RA occurrence, which demonstrated favorable performance in risk assessment and clinical decision-making through DCA evaluation. The gene discussed is ACADM; the disease is rheumatoid arthritis.