Using Random Survival Forest (RSF) analysis with importance scoring, we identified seven key prognostic genes (CD24, SLC25A5, HSPB1, CD9, SPIMK1, LGALS4, and CEACAM5; Figures 4B–D), which were subsequently designated as the Colorectal cancer Survival Signature (CSS). Here, HSPB1 is linked to colorectal cancer.