Using Random Survival Forest (RSF) analysis with importance scoring, we identified seven key prognostic genes (CD24, SLC25A5, HSPB1, CD9, SPIMK1, LGALS4, and CEACAM5; Figures 4B–D), which were subsequently designated as the Colorectal cancer Survival Signature (CSS). This evidence concerns the gene CD24 and colorectal cancer.