The transfer of CD4+CD25- T cells from Foxp3creCREBfl/fl ROSARFP mice (Figures 5A–G) and from VAVcreCREBfl/fl prevented the development of colitis (Supplementary Figure 11) and resulted in enhanced accumulation of RFP+ Tregs in different organs (Figures 5A–G). Here, CD4 is linked to colitis.