ONIDsc identified four gene transcripts: matrix remodelling-associated protein 8 (MXRA8), nicotinamide adenine dinucleotide kinase (NADK), RNA Polymerase III Subunit GL (POLR3GL) and Ultrabithorax Domain Protein 11 (UBXN11) in CD4+ T-lymphocytes, CD8+ Regulatory T-Lymphocytes, CD8+ T-lymphocytes 1 and Low Density Granulocytes that were present in SLE patients but absent in controls. The gene discussed is CD8A; the disease is systemic lupus erythematosus.