In summary, the results from the flow cytometry and RNA-seq analysis of the tumor immune environment suggest that loss of TG2 expression is associated with increases in CD4+ T cells and NK cells, increased B cell activation, and reduction of immunosuppressive TAMs that collectively slow the progression of metastasis in the ID8 Trp53-/- Brca1-/- model. Here, TGM2 is linked to neoplasm.