Syngeneic orthotopic transplant of ovarian cancer cells into transgenic mice lacking TG2 resulted in delayed metastasis, prolonged survival, and notable alterations in anti-tumor immune composition in mice harboring ID8 Trp53-/- Brca1-/- tumors, highlighting the importance of TG2 in the TME for disease progression. This evidence concerns the gene TGM2 and ovarian cancer.