While LaMarca reported that depleting rat B cells with anti-human CD20 (rituximab) reduced RUPP-induced hypertension (109, 110), Regal’s group found no such effect using anti-rat CD20 (111–113) where B cells in the blood and peritoneum were certainly depleted, but circulating IgM antibody was still apparent. The gene discussed is CD40LG; the disease is Hypertension.