GCG and obesity due to melanocortin 4 receptor deficiency: In a 4-week RCT involving patients with obesity and T2D, infusion of acombination of GLP-1, OXM, and Peptide YY (GOP) resulted in significantimprovements in glycemic control and moderate weight loss compared to placebo.GOP therapy also reduced fructosamine levels and improved postprandial glucosetolerance.