For instance, in obesity andMASLD/metabolic dysfunction-associated steatohepatitis (MASH), where energyimbalance and hepatic steatosis are dominant features, the thermogenic andlipolytic effects mediated by Gcg receptor activation provide a complementarymechanism to GLP-1-induced appetite suppression. This evidence concerns the gene GLP1R and obesity due to melanocortin 4 receptor deficiency.