While single-cell RNA sequencing (scRNA-seq) and AI offer transformativeinsights into PRP cellular heterogeneity and platelet subset functionalspecialization in cardiovascular disease, current applications overlook criticalclinical variables such as patient comorbidities (e.g., diabetes-induced platelethyperreactivity) and circulating factors (e.g., GDF11 modulating stem cellactivity). Here, GDF11 is linked to diabetes mellitus.