The high-mobility group box (HMGB) family iscomprised of four members (HMGB1-4) that play an important role in variousinflammatory diseases and have the capacity to modulate innate immunity [12].Research indicates that elevated HMGB1 levels are present in the aneurysmaltissue of human AAA and in murine experimental models of AAA [13]. This evidence concerns the gene HMGB1 and triple-A syndrome.