As shown in Table 7 and Fig. 3, an HMGB2 cut-off level of 3.110 ng/mLdiscriminated AAA patients from controls with a sensitivity of 60.6% andspecificity of 84.6% (AUC: 0.713, 95% CI: 0.588–0.839; p < 0.05).For HMGB1, the optimal cut-off value was 6.699 ng/mL, with a sensitivity of51.5% and specificity of 94.9% (AUC: 0.677, 95% CI: 0.541–0.813; p< 0.05). This evidence concerns the gene HMGB2 and triple-A syndrome.