In multivariate logisticregression analysis, after adjusting for age, smoking history (including bothcurrent and former smokers), hypertension, hyperlipidemia, statin use, anddiabetes (model 3), elevated levels of HMGB1 and HMGB2, and a decreased level ofsTREM-1 were found to be significantly associated with increased risk of AAA(p < 0.05) (Table 4). The gene discussed is HMGB2; the disease is hyperlipidemia.