Elevated HMGB2 and HMGB1 levels were associated with higher risks of AAA (HMGB2: OR: 1.158, 95% CI: 1.011–1.325; p < 0.05; HMGB1: OR: 1.275, 95% CI: 1.048–1.551; p < 0.05) and aneurysm rupture (HMGB2: OR: 1.117, 95% CI: 1.005–1.241; p < 0.05; HMGB1: OR: 1.212, 95% CI: 1.003–1.465; p < 0.05). The gene discussed is HMGB1; the disease is aneurysm.