In addition to theclassical pathway, Z-DNA binding protein 1 (ZBP1) has been identified as acrucial regulator of necroptosis, which is mainly caused by virus infection [53].In the pathophysiology of ZBP1-mediated necroptosis, ZBP1 recruits RIPK3 via itsRIP homotypic interaction motif (RHIM) domain and triggers theautophosphorylation of RIPK3. Here, RIPK3 is linked to viral infectious disease.