In this study, significant interactions were identifiedbetween the rs2000813 and rs3813082 loci of the endotheliallipase gene and environmental factors-including BMI, NE, PLT, WBC, hypertension,age, type 2 diabetes mellitus, TC, ApoB, smoking, alcohol consumption, andLp(a)-collectively influencing CHD risk in women. The gene discussed is APOB; the disease is hypertensive disorder.