Recent hospitalization for HF; elevated NT-proBNP ≥1000 pg/mL or BNP ≥250 pg/mL for patients in SR; or elevated NT-proBNP ≥2000 pg/mL or BNP ≥500 pg/mL for patients with AF; fulfilment of protocol-defined stabilization criteria; treatment with at least one intravenous dose of a loop diuretic. This evidence concerns the gene NPPB and atrial fibrillation.