AGT and cyclic hematopoiesis: Notably, the enhancement of METTL3levels resulted in a marked increase in cardiomyocyte size, demonstrating thatMETTL3 expression alone can effectively induce cardiomyocyte hypertrophy [213].JMJD1C, which functions as an H3K9me2-specific histone demethylase, isinstrumental in the process of CH and fibrosis triggered by Ang II by promotingthe transcription of TIMP1 [214].