In a recent study that appliedcapture-based bisulfite sequencing methods, researchers identified 151 regionsexhibiting differential methylation in DCM relative to non-failing hearts [165].A loss of miR-22 rendered mice more prone to the onset of dilated cardiomyopathyunder stressful conditions, with SIRT1 and HDAC4 identified as targets of miR-22in the cardiac environment. Here, SIRT1 is linked to familial dilated cardiomyopathy.