Whenpressure overload leads to a decrease in HTRA3 levels, it activates theTGF-β signaling pathway, potentially resulting in fibrosis and HF [194].Among the three epigenome-wide association studies (EWAS) conducted, hypertensivepatients exhibited lower methylation levels of SULF1, SKOR2,and EHMT2 when compared to normotensive individuals. This evidence concerns the gene EHMT2 and hydrops fetalis.