MHRTincreases KLF4 expression by either directly interacting withmiR-145a-5p or by forming a complex with KLF4 that prevents its phosphorylation.This action inhibits the binding of ERK to KLF4, which subsequently reducesmyocardin expression and lessens myocardial hypertrophy [381]. Here, KLF4 is linked to cardiac hypertrophy.