IFNK and systemic lupus erythematosus: This study aimed to identify whether epidermal-specific overexpression of IFN-κ (Ifnk) results in lupus-like cutaneous and systemic inflammation.<h4>Methods</h4>We compared 3-month-old (young) and 12-month-old (aged) Balb/c mice who overexpress Ifnk in the epidermis under the keratin 14 promoter (transgenic [TG]) with age-matched Balb/c wild-type mice and assessed local and systemic immune responses at baseline and after UV treatment.