Vitamin C has an anti-inflammatory effect because of its ability to inhibit NF-kB, which is responsible for the activation of inflammatory cytokines including IL-1, IL-6, IL-8 and TNF-alpha. Furthermore, its wound healing and anti-hyperpigmentation properties as well as antioxidant properties are important in the skin care for acne vulgaris patients.64 Here, TNF is linked to acne.