In addition to Th1/Th2 responses, Th17 immunity, characterized by IL‐17A and IL‐22 secretion, is also a critical type for mucosal protection against pathogen infection (viruses and bacteria).[36] Inspired by the significant enrichment of IL‐17 signaling in skin transcriptomic analysis, antigen‐triggered secretion level of IL‐17A and IL‐22 by splenocytes was assessed (Figure 9g). Here, IL22 is linked to infection.