Through this analysis, we defined 16 SCC‐specific genes, including FTH1, CDKN2A, BASP1, APP, ITGB1, GNAI2, MSN, LARP6, FLOT1, TPM4, PMEPA1, TNFRSF12A, LAMB3, TNC, ODC1, and MYL9, which are related to tumor progression and migration. The gene discussed is TNFRSF12A; the disease is neoplasm.