Consistent with a Carcinoma 3–T cell niche in SCC, robust signaling to Tregs was facilitated through multiple ligand–receptor interactions, encompassing TNFSF9‐TNFRSF9 and CXCL16‐CXCR6, as well as PTN‐SDC4, PVR‐CD96, and PVR‐TIGIT (Figure 5A). This evidence concerns the gene CXCL16 and carcinoma.