Furthermore, six tumor progression genes (GNAI2, ODC1, APP, TNFRSF12A, BASP1, and LARP6) and nine migration and metastasis‐related genes (MSN, FLOT1, LAMB3, MYL9, ITGB1, FTH1, TPM4, and PMEPA1), which could explain the invasive characteristics of SCC, were identified. The gene discussed is TPM4; the disease is neoplasm.