Through this analysis, we defined 16 SCC‐specific genes, including FTH1, CDKN2A, BASP1, APP, ITGB1, GNAI2, MSN, LARP6, FLOT1, TPM4, PMEPA1, TNFRSF12A, LAMB3, TNC, ODC1, and MYL9, which are related to tumor progression and migration. This evidence concerns the gene CDKN2A and neoplasm.