Final lists of highly contributing genes were reviewed (Additional file 1: Tables S24-S56) [28–163], which revealed adjustments necessary specifically for APC and BRAF. Nearly all the top genes with known associations with APC were linked to colorectal cancers, despite training across all tumour types (Additional file 1: Table S57) [28, 164–170], and the model’s performance was lacking across all tumour types, except colorectal cancer (Additional file 1: Figure S10). Here, APC is linked to neoplasm.