Furthermore, EZH2 mediates histone Histone H3 lysine 27 (H3K27) trimethylation (H3K27me3) and recruits the Polycomb repressive complex Polycomb Repressive Complex 1(PRC1), which inhibits the transcriptional activity of target genes, thereby enhancing DNA damage repair capability, promoting tumor cell proliferation, and inhibiting the apoptotic process, ultimately leading to the development of platinum drug resistance.[41]. Here, EZH2 is linked to neoplasm.