We find a similar pattern for colorectal cancer and ENST00000466964.1, an isoform of LAMC1 (six total isoforms), a gene that regulates cell adhesion, differentiation, migration, and signaling, and lies at a pleiotropic locus for CRC, PRCA [38], and obesity risk [63]. The gene discussed is LAMC1; the disease is obesity due to melanocortin 4 receptor deficiency.