Several key biological pathways are enriched for cancer-specific sets of isoTWAS-prioritized genes, including cell cycle and mitosis regulation, DNA and RNA binding, immune pathways, as well as downstream targets of cancer-relevant transcription factors like ESR1 [25], RUNX2 [26], and YY1 [27] (Supplemental Table S6, Supplemental Figs. S15–S20). This evidence concerns the gene ESR1 and cancer.