Also, the role of HPV-16 E7 oncoprotein in activation of EGFR–PI3K–AKT and NRF2, amplifying NFκB in driving tumor proliferation and survival is well known59,60, which was supported by the terms such as “phosphatidylinositol 3-kinase/protein kinase B signal transduction”, “canonical NF-kappaB signal transduction” in our finding. This evidence concerns the gene PIK3CA and neoplasm.