It is further worth noting that in the largest study included in this meta-analysis, the OPERA (Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation trial) trial, higher levels of preoperative NT-proBNP were observed in patients who later developed POAF but were not independently associated with the onset of POAF10. The gene discussed is NPPB; the disease is atrial fibrillation.