Moreover, the effectiveness of T2DM drugs, including metformin, sulfonylureas, dipeptidyl peptidase 4 (DPP-4) and sodium-glucose transport protein 2 (SGLT-2) inhibitors, may vary between individuals due to several factors including heredity, age, gender, hypertension and others [86]. The gene discussed is DPP4; the disease is type 2 diabetes mellitus.