In this experiment, CKD-AVF rats showed significant calcium salt deposition in AVF venous segment, and Sal B treatment significantly ameliorated calcium salt deposition; moreover, AVF venous segment and renal histopathological damage were significantly improved by Sal B treatment, which suggests that Sal B attenuates calcification and ameliorates tissue damage in CKD-AVF rats. The gene discussed is PPIB; the disease is chronic kidney disease.