Further analysis via KEGG pathway analysis revealed significant enrichment of pathways related to proteoglycans in cancer, ECM-receptor interaction, focal adhesion, and the PI3K-Akt signaling pathway, as well as pathways linked to human papillomavirus infection and heart-related conditions such as arrhythmogenic right ventricular cardiomyopathy (Fig. 8E). This evidence concerns the gene AKT1 and human papilloma virus infection.