SIRT1 and metabolic dysfunction-associated steatohepatitis: Furthermore, induction of the NAMPT/NAD+/SIRT1 axis in a methionine-choline-deficient diet-induced mouse model of NASH resulted in a significant reduction in liver inflammation, accompanied by a decrease in total bile acid levels throughout the enterohepatic circulation and a shift in the bile acid synthesis pathway from the classical to an alternative pathway, leading to a reduction in pro-inflammatory 12-OH bile acid production [78].