Within the CD4 compartment, CD4 TEM GZMK cells and all CD4 TREG clusters (CD4 TREG-CM1, CD4 TREG-CM2, CD4 TREG PD1, and CD4 TREG CD39) were also enriched in CLL LNs, in addition to proliferating TPR cells and DN TEM HELIOS cells (Fig. 3D). The gene discussed is ENTPD1; the disease is B-cell chronic lymphocytic leukemia.