Within the CD4 compartment, CD4 TEM GZMK cells and all CD4 TREG clusters (CD4 TREG-CM1, CD4 TREG-CM2, CD4 TREG PD1, and CD4 TREG CD39) were also enriched in CLL LNs, in addition to proliferating TPR cells and DN TEM HELIOS cells (Fig. 3D). Here, CD4 is linked to B-cell chronic lymphocytic leukemia.