In addition, several cytokines and chemokines with known relevance in CLL (TGFβ, CCL4, CCL5, IL16, IFNγ)35,36, as well as collagen and adhesion molecules (COL9A2/3 and ICAM-ITGAL) were predicted to be part of CLL-specific interactions (Fig. 6F). Here, CCL4 is linked to B-cell chronic lymphocytic leukemia.