The comparison of cell subset frequencies between CLL LNs and rLNs revealed that higher percentages of cytotoxic CD8 TEM GZMK as well as exhausted CD8+ T cells (CD8 TEX CD39 and CD8 TEX CD38) were present in CLL LNs (Fig. 3D). This evidence concerns the gene CD38 and B-cell chronic lymphocytic leukemia.