PLOD2 and nonpapillary renal cell carcinoma: To test this hypothesis, we first examined the role of PLOD2 alone in ccRCC and found that PLOD2 deletion led to a notable loss of EMT molecular characteristics (Fig. 5A, B) and a reduction in CSC markers (Fig. 5C, D) at both the mRNA and protein levels in 786-O and OS-RC-2 ccRCC cell lines.