The functional importance of both DCLK1-L and PLOD2 in hypoxia-driven ccRCC malignance, along with the validated PLOD2-DCLK1-L cascade in hypoxia signaling, prompted us to further examine the contribution of DCLK1-L to PLOD2-driven cancer invasiveness and stemness. This evidence concerns the gene PLOD2 and nonpapillary renal cell carcinoma.