We further revealed that procollagen lysyl hydroxylase 2 (PLOD2), a well-documented mediator of hypoxia-induced EMT [37, 38], acts downstream of HIF2α and plays an essential role in driving hypoxia-dependent preferential activation of DCLK1-L isoforms in ccRCC. Here, PLOD2 is linked to nonpapillary renal cell carcinoma.