Sarkar et al. reported that DCLK1-S, rather than DCLK1-L, significantly increased the invasive potential of human colon cancer cells and that high DCLK1-S levels, but not DCLK1-L, were associated with poorer overall survival in colorectal cancer patients, underscoring the major oncogenic role of DCLK1-S in colon cancer [69]. The gene discussed is DCLK1; the disease is colorectal cancer.