We validated β-catenin’s α-promoter binding activity by ChIP-qPCR in ccRCC (Fig. 4A) and further confirmed its capacity to selectively activate the α-promoter of DCLK1, as evidenced by the preferential upregulation of DCLK1-L over DCLK1-S upon β-catenin overexpression at the mRNA (Fig. 4B) and protein (Fig. 4C) levels in both 786-O and OS-RC-2 cell lines. This evidence concerns the gene DCLK1 and nonpapillary renal cell carcinoma.