We further revealed that procollagen lysyl hydroxylase 2 (PLOD2), a well-documented mediator of hypoxia-induced EMT [37, 38], acts downstream of HIF2α and plays an essential role in driving hypoxia-dependent preferential activation of DCLK1-L isoforms in ccRCC. The gene discussed is DCLK1; the disease is nonpapillary renal cell carcinoma.