To assess the oncogenic role of DCLK1-L in ccRCC, we performed loss-of-function studies by CRISPR/Cas9-mediated specific depletion of DCLK1-L variants in 786-O and OS-RC-2 ccRCC cell lines using DCLK1-L specific small guide RNAs. The gene discussed is DCLK1; the disease is nonpapillary renal cell carcinoma.