The expression of molecules associated with T cell exhaustion [29], such as PD-1, lymphocyte activation gene 3 (LAG-3), and T cell immunoglobulin, and mucin domain-containing 3 (TIM-3), decreased in tumor-infiltrating CAR-T cells compared with that in un-transduced T cells, especially in the presence of anti-PD-1 mAb (Fig. 6F). Here, LAG3 is linked to neoplasm.