Results showed that in Transwell migration and invasion assays, wound-healing assays, as well as in the mouse lung metastasis and spleen injection liver metastasis models employed in this study, ENO1 overexpression reversed the inhibitory effect of sh-LINC00183 on the metastatic potential of CRC cells, while sh-ENO1 transfection significantly attenuated the pro-metastatic phenotype driven by LINC00183 overexpression (Fig. 8I–L, N, O, Q, and U)(Supplementary Fig. S7E, F). This evidence concerns the gene JPX and colorectal carcinoma.