AKT1 and colonic neoplasm: Importantly, we also detected glucose deprivation-induced activation of AKT in HCT116 and SW620 human colon cancer cells, HepG2 human hepatocellular carcinoma (HCC) cells, Hepa 1-6 mouse HCC cells, MDA-MB-231 human breast cancer cells, and PY8119 and 4T1 murine mammary cancer cells (Fig. 1C).