We used MeRIP-seq and RNA-seq combined with multi-omics analysis to screen SNTB1 as a downstream target of ZC3H13, and demonstrated that SNTB1 was regulated by ZC3H13 in a m6A-modified manner and that ZC3H13 promoted the EMT process in GC cells, which was closely related to SNTB1 expression. This evidence concerns the gene ZC3H13 and gastric cancer.