Proving the participation of this alteration in the pathophysiology of HD, intraventricular injection of 4EGI-1, an inhibitor of eIF4G-eIF4E interaction, normalized translation efficiency levels, and ameliorated motor symptoms and corticostriatal long-term depression deficits in the R6/1 HD mouse model [2]. Here, EIF4G1 is linked to Huntington disease.