GSEA enrichment of KEGG Hippo signaling (Fig. 1G) and KEGG basal cell carcinoma (Fig. 1F) was driven by a strong enrichment for many genes related to wingless-related integration site (Wnt) signaling (e.g. WNT9A, WNT11, WNT5B, and WNT4) and bone morphogenetic protein (BMP) signaling (e.g. BMP2, BMP6, and BMPR1B) which have various profibrotic and antifibrotic functions in tissue fibrosis (24, 25, 26). This evidence concerns the gene BMP2 and basal cell carcinoma.