Although the role of ⍺-SMA+ myofibroblasts in WAT fibrosis is not completely understood, studies have shown the presence of ⍺-SMA+ ASC in WAT isolated from obese individuals, as well as increased WAT Acta2 expression in mouse models of diet-induced obesity (12, 37). Here, ACTA2 is linked to obesity due to melanocortin 4 receptor deficiency.