Although we did not study aged Prdx6 KO or mutant mice, previous results suggest that Prdx6-deficient animals exhibit increased susceptibility to oxidant stress in aging [99], a sarcopenic-like phenotype [38], and potentially other aging-related metabolic diseases [39,[100], [101], [102], [103], [104]]. This evidence concerns the gene PRDX6 and Other metabolic disease.