Reanalysis of our previous RNA sequencing (RNA-Seq) data (GSE235941) [4] of EBV latently infected naïve B-lymphocytes (0–4 days post-infection, dpi) as well as microarray data of EBV infected BL line BL31 [29] revealed significant transcriptional activation of E2F1 along with three other E2F members E2F2, E2F7 and E2F8 (S1A and S1B Fig). Here, E2F1 is linked to infection.