In sum, these results are consistent with a model in which E2F1 transcriptionally activates c-Myc and they independently repress BZLF1 expressions during EBV latent infection of naïve B-lymphocytes, whereas in response to periodic lytic cycle reactivation E2F1 and BZLF1 are present in a loop and negatively modulate each other’s expression (Fig 7D). This evidence concerns the gene E2F1 and disease arising from reactivation of latent virus.