Both qRT-PCR and immunoblot analysis of E2F1 depletion in P3HR1 and ectopic E2F1 expression in Jiyoye further confirmed the interdependence of E2F1 and c-Myc expressions in EBV positive B-cell lymphoma setting (Fig 6D-6G). This evidence concerns the gene MYC and B-cell non-Hodgkin lymphoma.