Moreover, there are two contradictory reports demonstrating while BZLF1 can induce E2F1 expression in primary keratinocytes and gastric carcinoma cells [25], E2F1 along with c-Myc obstruct BZLF1 mediated transactivation through a negative regulatory element located at the N-terminal region [26]. Here, E2F1 is linked to gastric carcinoma.