A study conducted by Siegl et al. has observed that, after treatment for GHS for 6 h, serum levels of IL-6, IL-10 and IL-1β are decreased, while serum level of TNF-α levels is increased in sepsis mice; after treatment for GHS for 24 h, similar trends are observed in serum levels of IL-10, IL-1β and TNF-α; after treatment for GHS for 48 h, the similar trend can still be observed in serum level of IL-1β [28]. Here, IL1B is linked to Sepsis.