These data showed that GAB2 inactivation markedly reduced the growth of 9 independent human AML cell lines (Figure 8B); we recapitulated these results with 2 GAB2-targeted guides (and an AAVS1 negative control) in K562 cells, which express the BCR::ABL fusion oncoprotein (Figure 8C). This evidence concerns the gene PPP1R12C and acute myeloid leukemia.