Gene Ontology (GO) enrichment analysis showed that gene sets with increased expression in the AML samples include “regulation of programmed cell death” (FDR < 0.001), “tumor necrosis factor superfamily cytokine production” (FDR < 0.01), “interleukin 6 production” (FDR = 0.01), and “kinase activity” (FDR < 0.001), while gene sets with decreased expression in the AML samples include “myeloid cell differentiation” (FDR < 1 × 10–32) and “lymphocyte activation” (FDR < 1 × 10–22) (Supplemental Table 2). The gene discussed is TNF; the disease is acute myeloid leukemia.