TP53 and acute myeloid leukemia: However, in human AML samples, the region of chromosome 11q14.1 containing GAB2 was amplified in only 1%–2% of cases (8, 56); data from clinical whole-genome sequencing performed on patients with AML at our institution identified amplification in 3.1% of cases (14 of 445), primarily in patients with TP53 mutations and/or complex karyotypes (57).