Overexpression of Gab2 in Npm1cA/+ bone marrow cells led to the development of AML in 7 of 7 engrafted mice with a median latency of 4.5 months, compared with a latency of 7.5 months with the IRES-eGFP–only vector (P = 0.12; Supplemental Figure 2A). Here, GAB2 is linked to acute myeloid leukemia.