Animal and human studies have demonstrated that APOE-ε4 is associated with lipid metabolism, amyloid burden, and gliosis, and interacts with diet-induced metabolic impairments in female animal models29,30,31; however, in our analysis, there were no interactions between the MIND diet and age at death (P for interaction = .10), sex (P for interaction = .68), or APOE-ε4 status (P for interaction = .39) (eTable 4 in Supplement 1). The gene discussed is APOE; the disease is Gliosis.