Although the original hypothesis of tumor recognition did not seem apparent, our data did frequently identify signatures expressing genes associated with a “less exhausted” cell phenotype as top prognosticators of OS and PFI (Caushi.stem-like memory, Caushi.CD8.Stem-like memory, B16_Prog.Ex_Miller, Jansen_Stem like, Krishna.ACT.CD8.Stem.Like, LCMV_Prog.EX_Miller) [9, 25, 28, 31]. The gene discussed is CD8A; the disease is neoplasm.