Although Zhang CD8 TCS had the lowest OS coefficient across ACC, KIRC, LUAD, PCPG and lowest PFI coefficient in KIRC, KIRP, LUAD, PCPG, and PRAD there is much more variability in top-performing signatures such as the Miller progenitor exhausted T-cell signature (B16_prog.Ex_miller), the Guo suppressive CD4 T-regulatory cell signature (Guo_Supp Treg), and the Chatani CD8 tumor recognition signature (Chatani_TP) having the lowest OS coefficients in BRCA, SKCM, and THYM, respectively. The gene discussed is CD8A; the disease is neoplasm.