CD8A and cancer: Despite this variability, two signatures were found to correlate with the OS coefficient across multiple tumor types: the Tang ferroptosis-related gene signature in head and neck squamous cell carcinoma (Tang_Ferroptosis) and Zhang.CD8.TCS, each seen across 4 cancer types (BLCA, CESC, HNSC, SARC and ACC, KIRC, LUAD, PCPG) (Fig. 4A, Table 3).