To further clarify the wide-ranging consequences of ASXL1-CH, including its potential links to aging-related accelerants such as smoking, obesity, and HIV infection, as well as its associations with autoimmune diseases, cardiovascular pathology, and solid tumors, both large-scale longitudinal epidemiological studies and experimentally validated in vivo models are needed. Here, ASXL1 is linked to obesity due to melanocortin 4 receptor deficiency.