Further, a study by Bick et al. also examined the prevalence of driver gene-mediated CH in individuals living with HIV, comparing with individuals of a larger population-based cohort, and demonstrated that people living with HIV have a two-fold increase in CH prevalence and that ASXL1 is the most commonly mutated CH-associated gene [56]. Here, ASXL1 is linked to cyclic hematopoiesis.