Cumbo et al. performed a targeted next-generation sequencing analysis in a cohort of 13 patients with IBD associated with hematological malignancies and observed that 11 patients (85%) harbor one or more mutations in CH-associated genes; DNMT3A was the most frequently mutated gene, followed by ASXL1 and JAK2 [7]. The gene discussed is ASXL1; the disease is hematologic disorder.