Experimental approaches for the underlying mechanism of the CH-disease association have primarily been driven by advances in research, mainly on TET2 and DNMT3A. Three independent groups, including ours, have recently investigated the association of ASXL1 mutations and CVD using distinct murine models for CVD, which is the most closely correlated with CH (Table 1). Here, DNMT3A is linked to cyclic hematopoiesis.