ASXL1 and acute myeloid leukemia: Similarly, our group generated a conditional Asxl1-mutant (mimicking ASXL1 E635RfsX15) knock-in (Rosa 26 locus) mouse model and found that the old mice with the Asxl1-mutant showed myeloid skewing, thrombocytosis, and mild anemia, without developing MDS or AML [82, 90].