A study on glioblastoma demonstrates that the knockdown of KDELC2 (encoding protein O-glucosyltransferase 3 targeting some EGF-LDs of NOTCH receptors) lowered POFUT1 transcript amount as well as those of NOTCH1-3 and HES1. It reduces p-PI3K, p-mTOR, and p-AKT quantities, implying that POFUT1 may indirectly contribute to the maintenance of the PI3K/AKT/mTOR pathway through regulation of the Notch one [65]. The gene discussed is HES1; the disease is glioblastoma.