A number of these human proteins, such as AGRIN (involved in the development of the neuromuscular junction), VWA2 (an extracellular matrix protein with a high gene expression in colorectal cancer cells [8]), and uPA (urokinase-type plasminogen activator, used as a tumor prognostic marker), were shown to be O-fucosylated by POFUT1, which is essential for their correct folding, stability, and functional activity [7, 9, 10]. Here, POFUT1 is linked to colorectal cancer.