Over the past decade, increasing evidence has linked the dysregulation of human protein O-fucosyltransferase 1 (POFUT1), overwhelmingly through gene overexpression, to tumor progression in multiple cancers, including colorectal, breast, gastric, lung, hepatocellular carcinoma, and glioblastoma. The gene discussed is POFUT1; the disease is hepatocellular carcinoma.