CFAP251 and colorectal carcinoma: In CRC cells, circPOFUT1 is overexpressed and functions as a miRNA sponge, specifically sequestering miR-653-5p, normally targeting the 3′UTR of E2F7. This competition increases the quantity of the transcription factor E2F7, which subsequently upregulates downstream targets like WD repeat-containing protein 66 (WDR66) linked to EMT, promoting CRC metastasis and chemoresistance [86].