SCARB1 and heart failure: Indeed, our data suggest that SCARB1 activation in ECs promotes an endothelial-mesenchymal transition–like state, and inhibition of SCARB1 reversed these phenotypes both in vitro and in vivo (Figures 4B to 4H, 5B to 5H, 6C, 6G, and 6H), highlighting the critical contribution of pathologic EC changes to heart failure progression.