Aside from amyloid-beta, multiple proteinopathies, including tau [5, 6], α-synuclein [7], TAR-DNA-binding protein 43 (TDP-43) [8], and vasculopathy [9] have been implicated in the pathogenesis of cognitive impairment in Lewy body disease (LBD). Here, TARDBP is linked to proteostasis deficiencies.